1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447
RKI-1447
CAS: 1342278-01-6
Molecular Formula: C16H14N4O2S
1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447 - Names and Identifiers
| Name | RKI-1447 |
| Synonyms | CS-855 RKI1447 RKI-1447 RKI1447 RKI 1447 1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447 |
| CAS | 1342278-01-6 |
| EINECS | 200-256-5 |
1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447 - Physico-chemical Properties
| Molecular Formula | C16H14N4O2S |
| Molar Mass | 326.37 |
| Density | 1.408±0.06 g/cm3(Predicted) |
| Melting Point | >205oC (dec.) |
| Solubility | 25°C: DMSO 65 mg/mL; Water <1 mg/mL; EtOH <1 mg/mL |
| Appearance | Solid |
| Color | Pale Yellow to Pale Beige |
| pKa | 6.36±0.70(Predicted) |
| Storage Condition | -20°C Freezer |
| MDL | MFCD26142658 |
| Use | RKI-1447 is an effective ROCK1 and ROCK2 inhibitor with IC50 of 14.5 nM and 6.2 nM respectively, and has anti-invasion and anti-tumor activities. |
1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.064 ml | 15.32 ml | 30.64 ml |
| 5 mM | 0.613 ml | 3.064 ml | 6.128 ml |
| 10 mM | 0.306 ml | 1.532 ml | 3.064 ml |
| 5 mM | 0.061 ml | 0.306 ml | 0.613 ml |
Last Update：2024-01-02 23:10:35
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View History
1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447
Atropic acid, ethyl ester
2-(二异丙胺基)甲基丙烯酸乙酯
2-氯-5-三氟甲基吡啶-4-硼酸
1-二苯基甲基氮杂啶-3-乙酸胺
聚(4-甲基-1-戊烯),中分子量
BENZOIC ACID, 5-BROMO-2-[[[(3-NITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-
2-氯-4-氟-5-碘苯甲酸甲酯
9-芴甲基 N-(2-溴乙基)氨基甲酸酯
乙基 2-甲基噻唑烷-4-羧酸酯
Atropic acid, ethyl ester
2-(二异丙胺基)甲基丙烯酸乙酯
2-氯-5-三氟甲基吡啶-4-硼酸
1-二苯基甲基氮杂啶-3-乙酸胺
聚(4-甲基-1-戊烯),中分子量
BENZOIC ACID, 5-BROMO-2-[[[(3-NITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-
2-氯-4-氟-5-碘苯甲酸甲酯
9-芴甲基 N-(2-溴乙基)氨基甲酸酯
乙基 2-甲基噻唑烷-4-羧酸酯